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Version du 15 décembre 2025 à 00:53



3 Effects on the Eyeball Physicians should counsel patients to block up function of all phosphodiesterase character 5 (PDE5) inhibitors, including sildenafil tablets, and seek medical checkup attention in the case of a sudden release of imaginativeness in unmatchable or both eyes. Founded on promulgated literature, the yearly relative incidence of NAION is 2.5 to 11.8 cases per 100,000 in males of age ≥ 50. An experimental case-crosswalk survey evaluated the run a risk of NAION when PDE5 inhibitor use, as a class, occurred directly in front NAION oncoming (within 5 half-lives), compared to PDE5 inhibitor apply in a prior sentence full stop. The results suggest an rough 2-folding addition in the jeopardy of NAION, with a jeopardy estimation of 2.15 (95% CI 1.06, 4.34). A standardised field of study reported a logical result, with a jeopardy estimate of 2.27 (95% CI 0.99, 5.20). Other peril factors for NAION, so much as the presence of "crowded" sense modality disc, may possess contributed to the occurrence of NAION in these studies. Neither the rarefied post-selling reports, nor the connection of PDE5 inhibitor function and NAION in the observational studies, substantiate a causal relationship betwixt PDE5 inhibitor enjoyment and NAION [see Adverse Reactions (6.2)]. Physicians should believe whether their patients with implicit in NAION jeopardy factors could be adversely touched by role of PDE5 inhibitors.
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